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How CBD Affects Hormones, Fat Loss, Athletic Performance, Sleep, Recovery & Much More

It’s cannabis time! The “Kentucky Castle” is a unique destination hotspot with a full biohacking facility, sauna, farm-to-table restaurant, precision medicine arm, hemp farm, horse facilities, and much more. It is owned by one of the physicians who hosts the “Wild Health” podcast, on which I was recently a guest. 

Recently, at the castle, I had the pleasure of giving a talk on how to hack your biology to get the most out of the genetics you were born with.

Afterward, I took part in a Q&A with several of the physicians in attendance at the conference, which you can also listen to here.

But during my time at the castle, I also had a chance to duck away with Dr. Matt Dawson, Dr. Michael Mallin, and CBD formulator and researcher Taylor Bright to discuss all things cannabis and CBD. We hit record on the mics and recorded all the hemp goodness for you on today’s episode.

In this episode, you’ll discover…

-The chemical effects of using marijuana…

  • Most often referring to tetrahydrocannabinol (THC) – the part of the cannabis plant that induces the euphoric state
  • THC levels have steadily risen from 3-5% in the 1960s to as high as 28% today
  • THC fits inside the CB1 receptor in the cerebral cortex of your brain (which causes the “high”)
  • Less often known is cannabidiol (CBD)
    • It’s one of over 80 cannabinoids in the hemp plant
    • It accounts for up to 40% of the plant’s total cannabinoid extract
  • CBD is more often researched for medical purposes than THC
  • How CBD and THC are separated
    • Hemp plants are grown with male plants fertilizing female plants
    • Remove the male plants, and the female plants produce THC (they produce very little THC when pollinated by the male plants)
    • Male and female plants together meet the international standard of <1% THC
    • Female plants contain other cannabinols with efficacious health benefits (CBG, CBGA, CBC, CBCA, CBDA)

-The effects of ingesting CBD with and without the THC cannabinol…

  • CBD serves as an antagonist to CB receptor agonists (a substance which initiates a physiological response when combined with a receptor)
    • In other words, CBD “mutes” the effects of the CB1 or CB2 receptors
  • CBD can elongate the “high” of THC by inhibiting the cytochrome p450 enzymes
  • Also an antagonist to the GPR55 cannabinol; found in the caudate nucleus section of the brain
  • Because CBD does not attach to the CB1 or CB2 receptors, it’s not addictive or habit forming
  • CBD acts as an agonist for the 5-HT 1A receptor (for anti-depressant, anti-anxiety effects)
  • It’s an allosteric modulator of your opioid receptors (for pain and chronic inflammation reduction)